In its manufacture, the chemical was contaminated with TCDD, or dioxin, "the most toxic substance known to humans", according to an investigation in the journal Science.
In his book Agent Orange on Trial published by Harvard University Press, Peter Schuck reported that companies who manufactured the defoliant knew "as early as 1952" that deadly dioxin had contaminated the chemical.
Between 1962 and 1971, the US military sprayed an estimated 80 million litres of Agent Orange and other herbicides on Vietnam, the journal Nature reported in 2003.
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